Faculty, Staff and Student Publications

Publication Date

1-18-2024

Journal

NPJ Breast Cancer

Abstract

In a 3-arm presurgical trial, four-six weeks exemestane 25 mg three times/week (TIW) was non-inferior to 25 mg/day (QD) in suppressing circulating estradiol in postmenopausal women with ER-positive breast cancer. Since obesity may decrease exemestane efficacy, we analyzed changes in sex steroids, adipokines, Ki-67, and drug levels in relation to obesity. Postmenopausal women with early-stage ER-positive breast cancer were randomized to either exemestane 25 mg QD (n = 57), 25 mg TIW (n = 57), or 25 mg/week (QW, n = 62) for 4-6 weeks before breast surgery. Serum and tissue pre- and post-treatment biomarkers were stratified by body mass index (BMI)< or ≥30 kg/m

Keywords

Cancer prevention, Randomized controlled trials

DOI

10.1038/s41523-024-00616-8

PMID

38238336

PMCID

PMC10796398

PubMedCentral® Posted Date

January 2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

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