Tagraxofusp Maintenance Post-Hematopoietic Stem Cell Transplantation Provides Long-Term Survival and Manageable Safety for a Patient With Blastic Plasmacytoid Dendritic Cell Neoplasm

Authors

Qaiser Bashir
Marina Konopleva
Glorette Abueg
Jeremy Ramdial
Chitra Hosing
Samer A Srour
Amin Alousi
Uday R Popat
Yago Nieto
Gheath Alatrash
Richard E Champlin
Elizabeth J Shpall
Muzaffar Qazilbash
Naveen Pemmaraju

Publication Date

1-1-2025

Journal

Leukemia Research Reports

DOI

10.1016/j.lrr.2025.100518

PMID

40612021

PMCID

PMC12213941

PubMedCentral® Posted Date

6-12-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Presented here is the case of a 68-year-old woman with blastic plasmacytoid dendritic cell neoplasm (BPDCN) treated with tagraxofusp (TAG) maintenance therapy post-allogeneic hematopoietic stem cell transplantation (allo-HCT). Prior to allo-HCT, the patient was treated with hydroxyurea and mini-CVD (cyclophosphamide, vincristine, and dexamethasone alternating with methotrexate (Methotrexate) and cytarabine) + venetoclax + TAG for 5 cycles, which induced morphologic complete remission with minimal residual disease. After allo-HCT, the patient had persistent cytogenic abnormalities 45,XX,der(7)add(7)(p13)del(7)(q11.2q22)add(7)(q32),add(12)(p13),-15,del(16)(q23),-17,+22,+2mar[1]/46,XX[19], and was then treated with TAG maintenance therapy at 9 mg/kg on a 28-day cycle for 16 cycles. At mid-treatment (cycle 6 of 16 cycles of TAG) and prior to TAG discontinuation (due to travel burden), the patient was negative for minimal residual disease and was in complete remission. There was no high-grade toxicity or capillary leak syndrome. The patient remains in complete remission as of present day (>17 months CR). This is the first case study illustrating the feasibility of long-term TAG maintenance post-allo-HCT to control BPDCN.

Published Open-Access

yes

Recommended Citation

Bashir, Qaiser; Konopleva, Marina; Abueg, Glorette; et al., "Tagraxofusp Maintenance Post-Hematopoietic Stem Cell Transplantation Provides Long-Term Survival and Manageable Safety for a Patient With Blastic Plasmacytoid Dendritic Cell Neoplasm" (2025). Faculty, Staff and Student Publications. 345.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/345