Tumor-Intrinsic SIRPA Promotes Sensitivity to Checkpoint Inhibition Immunotherapy in Melanoma

Authors

Wei Liu
Jun Li
Yitao Tang
Yining Zhao
Chaozhong Liu
Meiyi Song
Zhenlin Ju
Shwetha V Kumar
Yiling Lu
Rehan Akbani
Gordon B Mills
Han Liang

Publication Date

3-6-2025

Journal

Nature Communications

Abstract

Functional proteomics provides critical insights into cancer mechanisms, facilitating the discovery of novel biomarkers and therapeutic targets. We have developed a comprehensive cancer functional proteomics resource using reverse phase protein arrays, incorporating data from nearly 8000 patient samples from The Cancer Genome Atlas and approximately 900 samples from the Cancer Cell Line Encyclopedia. Our dataset includes a curated panel of nearly 500 high-quality antibodies, covering all major cancer hallmark pathways. To enhance the accessibility and analytic power of this resource, we introduce DrBioRight 2.0 ( https://drbioright.org ), an intuitive bioinformatic platform powered by state-of-the-art large language models. DrBioRight enables researchers to explore protein-centric cancer omics data, perform advanced analyses, visualize results, and engage in interactive discussions using natural language. By streamlining complex proteogenomic analyses, this tool accelerates the translation of large-scale functional proteomics data into meaningful biomedical insights.

Keywords

Humans, Neoplasms, Proteomics, Computational Biology, Software, Cell Line, Tumor, Biomarkers, Tumor, Cancer, Computational platforms and environments, Proteomics

DOI

10.1038/s41467-025-57430-4

PMID

40050282

PMCID

PMC11885830

PubMedCentral® Posted Date

3-6-2025

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes