Membranous Nephropathy in Chronic Lymphocytic Leukemia Responsive to Ibrutinib: A Case Report

Authors

Anna-Eve Turcotte
William F Glass
Jamie S Lin
Jan A Burger

Publication Date

1-1-2023

Journal

Leukemia Research Report

Abstract

Membranous nephropathy (MN) is an uncommon renal presentation in patients with chronic lymphocytic leukemia (CLL), and as such, there is no standard therapy for these patients. A few cases of MN in CLL have been described with varying success in MN treatment involving alkylating agents and fludarabine. Here we report the first case of MN in a patient with CLL treated with ibrutinib with complete renal response. This presentation underlines the importance of recognizing rare glomerular diseases that may occur with CLL and offers a new therapeutic avenue to the treatment of CLL-associated MN.

Keywords

Case report, Membranous nephropathy, Chronic lymphocytic leukemia, Bruton tyrosine kinase, Paraneoplastic

Comments

PMID: 37457553

DOI

10.1016/j.lrr.2023.100377

PMID

37457553

PMCID

PMC10338352

PubMedCentral® Posted Date

June 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes