Membranous Nephropathy in Chronic Lymphocytic Leukemia Responsive to Ibrutinib: A Case Report

Authors

Anna-Eve Turcotte
William F Glass
Jamie S Lin
Jan A Burger

Publication Date

1-1-2023

Journal

Leukemia Research Report

DOI

10.1016/j.lrr.2023.100377

PMID

37457553

PMCID

PMC10338352

PubMedCentral® Posted Date

June 2023

PubMedCentral® Full Text Version

Post-print

Abstract

Membranous nephropathy (MN) is an uncommon renal presentation in patients with chronic lymphocytic leukemia (CLL), and as such, there is no standard therapy for these patients. A few cases of MN in CLL have been described with varying success in MN treatment involving alkylating agents and fludarabine. Here we report the first case of MN in a patient with CLL treated with ibrutinib with complete renal response. This presentation underlines the importance of recognizing rare glomerular diseases that may occur with CLL and offers a new therapeutic avenue to the treatment of CLL-associated MN.

Keywords

Case report, Membranous nephropathy, Chronic lymphocytic leukemia, Bruton tyrosine kinase, Paraneoplastic

Published Open-Access

yes

Recommended Citation

Turcotte, Anna-Eve; Glass, William F; Lin, Jamie S; et al., "Membranous Nephropathy in Chronic Lymphocytic Leukemia Responsive to Ibrutinib: A Case Report" (2023). Faculty, Staff and Student Publications. 350.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/350