Harnessing the Therapeutic Vulnerability of Mmr Heterogeneity in Colorectal Cancer

Authors

Gayathri Anandappa
Michael J Overman

Publication Date

1-17-2023

Journal

Cell Reports Medicine

DOI

10.1016/j.xcrm.2022.100908

PMID

36652917

PMCID

PMC9873932

PubMedCentral® Posted Date

1-17-2023

PubMedCentral® Full Text Version

Post-print

Abstract

In a recent issue of Cancer Cell, Amodio and colleagues report an interesting method of modulating immunosurveillance in colorectal tumors with DNA mismatch repair (MMR) heterogeneity.1 By pharmacologically enriching the MMR deficient (MMRd) component using 6-thioguanine, they demonstrate improved tumor control in murine models.

Keywords

Animals, Mice, DNA Mismatch Repair, Colorectal Neoplasms, Thioguanine

Published Open-Access

yes

Recommended Citation

Gayathri Anandappa and Michael J Overman, "Harnessing the Therapeutic Vulnerability of Mmr Heterogeneity in Colorectal Cancer" (2023). Faculty, Staff and Student Publications. 3704.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/3704