miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities

Authors

Wilson Huang
Doru Paul
George A Calin
Recep Bayraktar

Publication Date

12-30-2023

Journal

Cells

Abstract

MicroRNAs (miRNAs) are a type of non-coding RNA whose dysregulation is frequently associated with the onset and progression of human cancers. miR-142, an ultra-conserved miRNA with both active -3p and -5p mature strands and wide-ranging physiological targets, has been the subject of countless studies over the years. Due to its preferential expression in hematopoietic cells, miR-142 has been found to be associated with numerous types of lymphomas and leukemias. This review elucidates the multifaceted role of miR-142 in human physiology, its influence on hematopoiesis and hematopoietic cells, and its intriguing involvement in exosome-mediated miR-142 transport. Moreover, we offer a comprehensive exploration of the genetic and molecular landscape of the miR-142 genomic locus, highlighting its mutations and dysregulation within hematological malignancies. Finally, we discuss potential avenues for harnessing the therapeutic potential of miR-142 in the context of hematological malignancies.

Keywords

Humans, Hematologic Neoplasms, Leukemia, Exosomes, Genomics, MicroRNAs

Comments

PMID: 38201290

DOI

10.3390/cells13010084

PMID

38201290

PMCID

PMC10778542

PubMedCentral® Posted Date

December 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes