Normalization of Temperature Effects for Quality Assurance of Quantitative Prostate Apparent Diffusion Coefficient Imaging Across Multiple Sites

Authors

Ken-Pin Hwang
Joshua Yung
R Jason Stafford
Caroline Chung
Aradhana M Venkatesan

Language

English

Publication Date

12-1-2025

Journal

Journal of Applied Clinical Medical Physics

DOI

10.1002/acm2.70311

PMID

41310358

PMCID

PMC12660052

PubMedCentral® Posted Date

11-27-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Background: Apparent Diffusion Coefficient (ADC) as measured by diffusion weighted imaging is known to negatively correlate with prostate tumor aggressiveness. Heterogeneity in system and protocol performance causes potential variability in ADC acquired across a large scanner network, prompting a need to evaluate quantitative ADC from a prostate-specific MR diffusion protocol as part of quality assurance (QA). Due to the temperature dependence of ADC, repeatability and reproducibility assessments typically require phantoms to maintain a temperature of 0°C, imposing a considerable burden when assessing large numbers of scanners.

Purpose: To develop a QA procedure at room temperature for assessing the reproducibility of ADC measured by our prostate diffusion MRI protocols, by employing a model relating ADC and phantom gel concentration to temperature.

Methods: A diffusion phantom was imaged with our clinical prostate diffusion protocols on 1.5 T (n = 4) and 3 T (n = 4) scanners in separate geographical locations (n = 4). Phantom temperature was not strictly controlled but measured immediately before and after each acquisition. Regions of interest were drawn in phantom compartments to produce ADC measurements at varying phantom gel concentrations. The ADC temperature model was applied using measured temperatures to produce normalized ADC measurements at a reference temperature of 20°C. Percent difference and coefficient of variation (CV) calculations were performed on the measurements with and without normalization.

Results: Temperature normalization reduced the range of ADC percent difference across scanners. The maximum CV of clinically relevant ADC values was reduced from 5.0% to 3.4% when normalized to the temperature model, while CV of pure water was reduced from 3.3% to 1.3%.

Conclusion: We have developed a QA procedure that incorporates a temperature model to obviate the need for strict temperature control of a diffusion phantom, facilitating ADC reproducibility assessments of a prostate diffusion MRI protocol across a large scanner network.

Keywords

Humans, Phantoms, Imaging, Prostatic Neoplasms, Male, Diffusion Magnetic Resonance Imaging, Quality Assurance, Health Care, Temperature, Image Processing, Computer-Assisted, Reproducibility of Results, apparent diffusion coefficient, diffusion weighted imaging, prostate imaging, quality assurance, temperature effects on diffusion

Published Open-Access

yes

Recommended Citation

Hwang, Ken-Pin; Yung, Joshua; Stafford, R Jason; et al., "Normalization of Temperature Effects for Quality Assurance of Quantitative Prostate Apparent Diffusion Coefficient Imaging Across Multiple Sites" (2025). Faculty, Staff and Student Publications. 4142.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4142