Sample Multiplexing in CyTOF: Path To Optimize Single-Cell Proteomic Profiling

Authors

Muharrem Muftuoglu
Michael Andreeff

Publication Date

1-1-2024

Journal

Cell Signaling

DOI

10.46439/signaling.2.041

PMID

40182016

PMCID

PMC11967567

PubMedCentral® Posted Date

4-3-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Sample multiplexing significantly enhanced the depth of single-cell proteomic analysis in CyTOF (Cytometry by Time-Of-Flight). New polymer-based chelators have broadened the utility of metal isotopes, enabling improved tagging and simultaneous analysis of multiple samples. These approaches minimize batch effects, streamline experiments, conserve valuable samples, reduce costs, enhance throughput, and increase the accuracy of biological data, thereby facilitating novel discoveries.

Published Open-Access

yes

Recommended Citation

Muharrem Muftuoglu and Michael Andreeff, "Sample Multiplexing in CyTOF: Path To Optimize Single-Cell Proteomic Profiling" (2024). Faculty, Staff and Student Publications. 4223.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4223