In Vivo Assessment of Cardiac Radiofrequency Ablation in a Large-Animal Model Using Photoacoustic-Ultrasound Imaging

Authors

Nilesh Mathuria
Krithik Vishwanath
Blake C Fallon
Antonio Martino
Giorgio Brero
Richard C Willson
Miguel Valderrabano
Carly S Filgueira
Richard R Bouchard

Publication Date

5-1-2025

Journal

JACC: Clinical Electrophysiology

DOI

10.1016/j.jacep.2025.02.031

PMID

40310313

PMCID

PMC12276966

PubMedCentral® Posted Date

7-20-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Despite advancements in catheter technology, intraoperative assessment of radiofrequency ablation (RFA) lesions remains elusive. Prior ex vivo data suggest photoacoustic imaging (PAI) can provide RFA lesion characteristics, but in vivo data are lacking. PAI involves delivering near-infrared light to tissue, leading to transient acoustic waves that can be detected by clinically available ultrasound transducers, providing optically based tissue characterization at depth. Three epicardial RFA lesions were delivered in an open-chest porcine model. In vivo PAI-based measurements of RFA lesion dimensions matched (< 0.7-mm error) gross pathologic assessment, yielding in vivo feasibility data of PAI to provide intraoperative RFA lesion dimensions.

Keywords

Animals, Photoacoustic Techniques, Swine, Catheter Ablation, Ultrasonography, Models, Animal, Radiofrequency ablation, photoacoustic imaging, ultrasound, catheter ablation, ventricular tachycardia

Published Open-Access

yes

Recommended Citation

Mathuria, Nilesh; Vishwanath, Krithik; Fallon, Blake C; et al., "In Vivo Assessment of Cardiac Radiofrequency Ablation in a Large-Animal Model Using Photoacoustic-Ultrasound Imaging" (2025). Faculty, Staff and Student Publications. 4255.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4255