Faculty, Staff and Student Publications

Publication Date

7-1-2024

Journal

Radiology

DOI

10.1148/radiol.232654

PMID

39078294

PMCID

PMC11294769

PubMedCentral® Posted Date

7-30-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Systemic immunotherapies have led to tremendous progress across the cancer landscape. However, several challenges exist, potentially limiting their efficacy in the treatment of solid tumors. Direct intratumoral injection can increase the therapeutic index of immunotherapies while overcoming many of the barriers associated with systemic administration, including limited bioavailability to tumors and potential systemic safety concerns. However, challenges remain, including the lack of standardized approaches for administration, issues relating to effective drug delivery, logistical hurdles, and safety concerns specific to this mode of administration. This article reviews the biologic rationale for the localized injection of immunotherapeutic agents into tumors. It also addresses the existing limitations and practical considerations for safe and effective implementation and provide recommendations for optimizing logistics and treatment workflows. It also highlights the critical role that radiologists, interventional radiologists, and medical physicists play in intratumoral immunotherapy with respect to target selection, image-guided administration, and response assessment.

Keywords

Humans, Immunotherapy, Neoplasms, Injections, Intralesional

Published Open-Access

yes

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