Faculty, Staff and Student Publications

Publication Date

8-1-2025

Journal

Oral Oncology

DOI

10.1016/j.oraloncology.2025.107337

PMID

40516152

PMCID

PMC12276996

PubMedCentral® Posted Date

7-20-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Purpose: This study aims to identify radiomic features from contrast-enhanced CT (CECT) scans that differentiate osteoradionecrosis (ORN) from normal mandibular bone in head and neck cancer (HNC) patients treated with radiotherapy (RT).

Materials and methods: CECT images from 150 patients with confirmed ORN diagnosis (2008-2018) at MD Anderson Cancer Center (MDACC) were analyzed (80 % train, 20 % test). Radiomic features were extracted using PyRadiomics from manually segmented ORN regions and automated contralateral healthy mandible regions. Correlation analysis (r > 0.95) reduced features for model training. A random Forest (RF) classifier with Recursive Feature Elimination identified discriminative features. Explainability was assessed using SHapley Additive exPlanations (SHAP) analysis on the 20 most important features identified by the trained RF classifier.

Results: Of the 1316 radiomic features extracted, 810 features were excluded for high collinearity. From a set of 506 pre-selected radiomic features, 67 were optimal for RF classification, yielding 88% accuracy and a ROC AUC of 0.96. The model well calibrated (Log Loss 0.296, ECE 0.125) and achieved an accuracy of 88% and a ROC AUC of 0.96. The SHAP analysis revealed that higher values of Wavelet-LLH First order Mean and Median were associated with ORN of the jaw (ORNJ). Conversely, higher Exponential GLDM Dependence Entropy and lower Square First-order Kurtosis were more characteristic of normal mandibular tissue.

Conclusion: This study successfully developed a CECT-based radiomics model for differentiating ORNJ from healthy mandibular tissue in HNC patients after RT. Future work will focus on detecting subclinical ORNJ regions to guide earlier interventions.

Keywords

Humans, Osteoradionecrosis, Head and Neck Neoplasms, Male, Female, Tomography, X-Ray Computed, Middle Aged, Aged, Cancer Survivors, Cross-Sectional Studies, Mandible, Mandibular Diseases, Adult, Radiomics

Published Open-Access

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