Regulation of hnRNPA1 by microRNAs Controls the miR-18a–K-RAS Axis in Chemotherapy-Resistant Ovarian Cancer

Authors

Cristian Rodriguez-Aguayo
Paloma Del C Monroig
Roxana S Redis
Emine Bayraktar
Maria I Almeida
Cristina Ivan
Enrique Fuentes-Mattei
Mohammed H Rashed
Arturo Chavez-Reyes
Bulent Ozpolat
Rahul Mitra
Anil K Sood
George A Calin
Gabriel Lopez-Berestein

Publication Date

1-1-2017

Journal

Cancer Discovery

DOI

10.1038/celldisc.2017.29

PMID

28904816

PMCID

PMC5594916

PubMedCentral® Posted Date

9-12-2017

PubMedCentral® Full Text Version

Post-print

Abstract

The regulation of microRNA (miRNA) biogenesis, function and degradation involves a range of mechanisms, including interactions with RNA-binding proteins. The potential contribution of regulatory miRNAs to the expression of these RNA interactor proteins that could control other miRNAs expression is still unclear. Here we demonstrate a regulatory circuit involving oncogenic and tumor-suppressor miRNAs and an RNA-binding protein in a chemotherapy-resistant ovarian cancer model. We identified and characterized miR-15a-5p and miR-25-3p as negative regulators of hnRNPA1 expression, which is required for the processing of miR-18a-3p, an inhibitor of the

Keywords

chemotherapy resistance, hnRNPA1, K-RAS, microRNAs, ovarian cancer, RNA-binding proteins

Comments

This article has been corrected. See Cell Discov. 2023 Nov 8;9:111.

Published Open-Access

yes

Recommended Citation

Rodriguez-Aguayo, Cristian; Monroig, Paloma Del C; Redis, Roxana S; et al., "Regulation of hnRNPA1 by microRNAs Controls the miR-18a–K-RAS Axis in Chemotherapy-Resistant Ovarian Cancer" (2017). Faculty, Staff and Student Publications. 4281.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4281