Faculty, Staff and Student Publications

Publication Date

7-1-2025

Journal

Nature Reviews Clinical Oncology

DOI

10.1038/s41571-025-01021-1

PMID

40379986

PMCID

PMC12227073

PubMedCentral® Posted Date

7-4-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

The treatment landscape of non-small-cell lung cancer (NSCLC) is evolving rapidly, driven by advances in the development of targeted agents and immunotherapies. Despite this progress, some patients have suboptimal responses to treatment, highlighting the need for new therapeutic strategies. In the past decade, the important role of the tumour microenvironment (TME) in NSCLC progression, metastatic dissemination and response to treatment has become increasingly evident. Understanding the complexity of the TME and its interactions with NSCLC can propel efforts to improve current treatment modalities, overcome resistance and develop new treatments, which will ultimately improve the outcomes of patients. In this Review, we provide a comprehensive view of the NSCLC TME, examining its components and highlighting distinct archetypes characterized by spatial niches within and surrounding tumour nests, which form complex neighbourhoods. Next, we explore the interactions within these components, focusing on how inflammation and immunosuppression shape the dynamics of the NSCLC TME. We also address the emerging influences of patient-related factors, such as ageing, sex and health disparities, on the NSCLC-TME crosstalk. Finally, we discuss how various therapeutic strategies interact with and are influenced by the TME in NSCLC. Overall, we emphasize the interconnectedness of these elements and how they influence therapeutic outcomes and tumour progression.

Keywords

Humans, Tumor Microenvironment, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Disease Progression, Immunotherapy

Published Open-Access

yes

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