One Form and Two Functions: MBD of SETDB2 Is a Protein-Interacting Domain

Authors

Jujun Zhou
Taiping Chen
Xiaodong Cheng

Publication Date

3-7-2024

Journal

Structure

DOI

10.1016/j.str.2024.01.009

PMID

38458157

PMCID

PMC12266713

PubMedCentral® Posted Date

7-16-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

In this issue of Structure, Mahana et al.1 present their structural characterization of an annotated methyl-CpG-binding domain (MBD) from the histone H3 lysine 9 methyltransferase SETDB2. This study reveals that, rather than binding DNA as previously hypothesized, this domain instead interacts with a cystine-rich domain from C11orf46, highlighting its involvement in protein-protein interactions.

Keywords

DNA Methylation, DNA-Binding Proteins, DNA, Methyltransferases

Published Open-Access

yes

Recommended Citation

Jujun Zhou, Taiping Chen, and Xiaodong Cheng, "One Form and Two Functions: MBD of SETDB2 Is a Protein-Interacting Domain" (2024). Faculty, Staff and Student Publications. 4294.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4294