T-Cell Dysfunctions in Myelodysplastic Syndromes

Authors

Juan Jose Rodriguez-Sevilla
Simona Colla

Publication Date

4-4-2024

Journal

Blood

DOI

10.1182/blood.2023023166

PMID

38237139

Abstract

Escape from immune surveillance is a hallmark of cancer. Immune deregulation caused by intrinsic and extrinsic cellular factors, such as altered T-cell functions, leads to immune exhaustion, loss of immune surveillance, and clonal proliferation of tumoral cells. The T-cell immune system contributes to the pathogenesis, maintenance, and progression of myelodysplastic syndrome (MDS). Here, we comprehensively reviewed our current biological knowledge of the T-cell compartment in MDS and recent advances in the development of immunotherapeutic strategies, such as immune checkpoint inhibitors and T-cell- and antibody-based adoptive therapies that hold promise to improve the outcome of patients with MDS.

Keywords

Humans, Myelodysplastic Syndromes, T-Lymphocytes, Clone Cells

Published Open-Access

yes

Recommended Citation

Juan Jose Rodriguez-Sevilla and Simona Colla, "T-Cell Dysfunctions in Myelodysplastic Syndromes" (2024). Faculty, Staff and Student Publications. 4303.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4303