Faculty, Staff and Student Publications
Publication Date
6-2-2025
Journal
Molecular Pharmaceutics Journal
DOI
10.1021/acs.molpharmaceut.4c01456
PMID
40359181
PMCID
PMC12135058
PubMedCentral® Posted Date
5-13-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Manipulating biology through chemistry is older than the discipline of chemistry itself. Traditionally, selectivity of oral or intravenous drugs relied on preferential drug-receptor binding. A novel approach exploiting image-guided techniques to impart spatial selectivity opens up a wide range of new possibilities for study and manipulation of biology. Motivated initially by the poor prognosis for solid tumors such as liver cancer, we demonstrate the use of an extreme form of in vivo chemistry for targeted delivery of 2-propylpentanoyl chloride in a swine model. The ensuing reaction in tissue devitalizes it by multiple mechanisms with lasting effects and, critically, demonstrates very low systemic exposure compared to controls. This work points toward a new, powerful strategy for investigating the interface between chemistry and biology in vivo.
Keywords
Animals, Chemistry, Pharmaceutical, Drug Delivery Systems, Hydrophobic and Hydrophilic Interactions, Pilot Projects, Swine, Tissue Distribution, hepatocellular carcinoma, liver cancer, transarterial chemoembolization, covalent modification, image-guided chemistry, thermoembolization
Published Open-Access
yes
Recommended Citation
Cressman, Erik; Stolley, Danielle; Fowlkes, Natalie; et al., "Harnessing Electrophiles In Vivo: A Pilot Study in Swine Using a Hydrophobic Radiopaque Formulation of 2-Propylpentanoyl Chloride" (2025). Faculty, Staff and Student Publications. 4315.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4315
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons