Human Pain Neuroscience and the Next Generation of Pain Therapeutics

Authors

Bryan A Copits
Michele Curatolo
Patrick M Dougherty
Robert W Gereau
Wenqin Luo
Maryann Martone
Hakan Olausson
Theodore J Price
William Renthal
Clifford J Woolf
Guoyan Zhao

Publication Date

5-7-2025

Journal

Neuron

DOI

10.1016/j.neuron.2025.04.005

PMID

40339567

PMCID

PMC12279253

PubMedCentral® Posted Date

7-21-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

The recent approval of suzetrigine for acute pain treatment highlights both the success of targeting peripheral sensory neurons for pain management and the potential of developing new pain therapies primarily in human-based systems. To realize this transformative potential, further research into somatosensation and pain neuroimmunology in human systems is essential.

Keywords

Animals, Humans, Analgesics, Neurosciences, Pain, Pain Management, Sensory Receptor Cells

Published Open-Access

yes

Recommended Citation

Copits, Bryan A; Curatolo, Michele; Dougherty, Patrick M; et al., "Human Pain Neuroscience and the Next Generation of Pain Therapeutics" (2025). Faculty, Staff and Student Publications. 4363.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4363