Faculty, Staff and Student Publications
Publication Date
7-18-2025
Journal
iScience
DOI
10.1016/j.isci.2025.112973
PMID
40687816
PMCID
PMC12275058
PubMedCentral® Posted Date
6-24-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Pulmonary capillary endothelial cells (ECs) consist of two populations, CAP1 and CAP2; how each population reacts to diverse tissue injury is incompletely understood. Using single-cell multiome and mouse genetics, we characterize the induction and function of a truncated isoform of Ntrk2, Ntrk2-T1, in multiple lung injury models. Upon Sendai parainfluenza infection, Ntrk2-T1 is broadly induced in CAP1s after the initial interferon response, associated with increased intronic chromatin accessibility, and persists for weeks. Ntrk2-T1 ECs arise from CAP1s but not CAP2s-traced by
Keywords
Biochemistry, Molecular physiology, Cell biology
Published Open-Access
yes
Recommended Citation
Kong, Celine Shuet Lin; V, Mitheera; Pantaleón-García, Jezreel; et al., "Truncated NTRK2 Is Induced in CAP1 Endothelial Cells During Mouse Lung Injury-Repair" (2025). Faculty, Staff and Student Publications. 4375.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4375
Graphical Abstract
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Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons