Multifocal and Multicentric Glioblastoma: Imaging Signature, Molecular Characterization, Patterns of Spread, and Treatment

Authors

Maguy Farhat
Gregory N Fuller
Max Wintermark
Caroline Chung
Vinodh A Kumar
Melissa Chen

Publication Date

8-10-2023

Journal

The Neuroradiology Journal

DOI

10.1177/19714009231193162

PMID

37559514

PubMedCentral® Posted Date

8-10-2023

Abstract

Multifocal and multicentric glioblastoma (GBM) or collectively, m-GBM, is an imaging diagnosis present in up to 34% of patients with GBM. Compared to unifocal disease, patients with m-GBM have worse outcomes owing to the enhanced aggressive nature of the disease and its resistance to currently available treatments. To improve the understanding of its complex behavior, many associations have been established between the radiologic findings of m-GBM and its gross histology, genetic composition, and patterns of spread. Additionally, the holistic knowledge of the exact mechanisms of m-GBM genesis and progression is crucial for identifying potential targets permitting enhanced diagnosis and treatment. In this review, we aim to provide a comprehensive summary of the cumulative knowledge of the unique molecular biology and behavior of m-GBM and the association of these features with neuroimaging.

Published Open-Access

yes

Recommended Citation

Farhat, Maguy; Fuller, Gregory N; Wintermark, Max; et al., "Multifocal and Multicentric Glioblastoma: Imaging Signature, Molecular Characterization, Patterns of Spread, and Treatment" (2023). Faculty, Staff and Student Publications. 4390.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4390