Faculty, Staff and Student Publications

Publication Date

5-9-2024

Journal

American Journal of Neuroradiology

DOI

10.3174/ajnr.A8192

PMID

38637027

PMCID

PMC11288540

PubMedCentral® Posted Date

5-1-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Primary intracranial sarcoma, DICER1-mutant, is a rare, recently described entity in the fifth edition of the WHO Classification of CNS Tumors. Given the entity's rarity and recent description, imaging data on primary intracranial sarcoma, DICER1-mutant, remains scarce. In this multicenter case series, we present detailed multimodality imaging features of primary intracranial sarcoma, DICER1-mutant, with emphasis on the appearance of the entity on MR imaging. In total, 8 patients were included. In all 8 patients, the lesion demonstrated blood products on T1WI. In 7 patients, susceptibility-weighted imaging was obtained and demonstrated blood products. Primary intracranial sarcoma, DICER1-mutant, is a CNS neoplasm that primarily affects pediatric and young adult patients. In the present case series, we explore potential imaging findings that are helpful in suggesting this diagnosis. In younger patients, the presence of a cortical lesion with intralesional blood products on SWI and T1-weighted MR imaging, with or without extra-axial blood products, should prompt the inclusion of this entity in the differential diagnosis.

Keywords

Humans, Ribonuclease III, DEAD-box RNA Helicases, Male, Female, Brain Neoplasms, Mutation, Adolescent, Young Adult, Adult, Magnetic Resonance Imaging, Sarcoma, Child, Child, Preschool

Published Open-Access

yes

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