Faculty, Staff and Student Publications

Publication Date

1-1-2024

Journal

Frontiers in Urology

DOI

10.3389/fruro.2024.1419418

PMID

40777103

PMCID

PMC12327261

PubMedCentral® Posted Date

5-22-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Introduction: This review aims to analyze the existing literature on local recurrence (LR) in patients undergoing partial nephrectomy (PN) for renal cell carcinoma, identifying relative risk factors, and exploring optimal clinical management strategies.

Methods: A comprehensive literature search was conducted across bibliographic databases, primarily focusing on LR rates. Secondary outcomes included evaluation of positive surgical margins (PSM), nephrometry scores, pathological stage (T and grading), perioperative outcomes, time-to-LR, overall survival, and cancer-specific survival.

Results: Due to the heterogeneity, a narrative synthesis was performed. LR rates after PN varied in the literature; with PSM emerging as a significant risk factor. Other LR risk factors included pathological stage, nephrometry scores, and histological variants. However, evidence regarding optimal LR management in the absence of precise indications was lacking.

Conclusion: LR represents a significant clinical challenge; requiring multidisciplinary assessment and shared decision-making with patients. Given well-established risk factors, clinicians must tailor management strategies to optimize patient outcomes.

Keywords

local recurrence, partial nephrectomy, positive surgical margin, prognostic factor, review, renal cell carcinoma

Published Open-Access

yes

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