Sickle Cell Disease Induces Chromatin Introversion and Ferroptosis in CD8+ T Cells To Suppress Anti-Tumor Immunity

Authors

Zilong Zhao
Benxia Hu
Yalan Deng
Melinda Soeung
Jun Yao
Lanxin Bei
Yaohua Zhang
Pengju Gong
Lisa A Huang
Zhou Jiang
Jian Gao
Shuang Peng
Tina K Nguyen
Menuka Karki
Bora Lim
Cassian Yee
Jared K Burks
Qing Zhang
Li Ma
Jianjun Gao
Nizar M Tannir
Leng Han
Dihua Yu
Linghua Wang
Michael A Curran
Maria A Gubbiotti
Giannicola Genovese
Boyi Gan
Wenbo Li
Pavlos Msaouel
Liuqing Yang
Chunru Lin

Publication Date

6-10-2025

Journal

Immunity

DOI

10.1016/j.immuni.2025.04.020

PMID

40359940

PMCID

PMC12186235

PubMedCentral® Posted Date

6-10-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Understanding how genetic disorders affect CD8

Keywords

Ferroptosis, Animals, CD8-Positive T-Lymphocytes, Mice, Anemia, Sickle Cell, Humans, Chromatin, Tumor Microenvironment, Amino Acid Transport System y+, Neoplasms, Disease Models, Animal, Mice, Inbred C57BL

Published Open-Access

yes

Recommended Citation

Zhao, Zilong; Hu, Benxia; Deng, Yalan; et al., "Sickle Cell Disease Induces Chromatin Introversion and Ferroptosis in CD8+ T Cells To Suppress Anti-Tumor Immunity" (2025). Faculty, Staff and Student Publications. 4426.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4426