A Single-Cell Atlas of CD19 Chimeric Antigen Receptor T Cells

Authors

Xubin Li
Jared Henderson
Max J Gordon
Irtiza Sheikh
Loretta J Nastoupil
Jason Westin
Christopher Flowers
Sairah Ahmed
Linghua Wang
Sattva S Neelapu
Paolo Strati
Qing Deng
Michael R Green

Publication Date

11-13-2023

Journal

Cancer Cell

DOI

10.1016/j.ccell.2023.08.015

PMID

37738975

Abstract

Li et al. present a resource of single-cell RNA sequencing (scRNA-seq) data from the infusion products of relapsed or refractory large B cell lymphoma (rrLBCL) patients treated with standard-of-care axicabtagene ciloleucel and identify features that are significantly different between products from responders and non-responders at 3-month followup by PET/CT, an important landmark for long-term outcomes.

Keywords

Humans, Receptors, Chimeric Antigen, Positron Emission Tomography Computed Tomography, Immunotherapy, Adoptive, Lymphoma, Large B-Cell, Diffuse, Antigens, CD19, T-Lymphocytes

Published Open-Access

yes

Recommended Citation

Li, Xubin; Henderson, Jared; Gordon, Max J; et al., "A Single-Cell Atlas of CD19 Chimeric Antigen Receptor T Cells" (2023). Faculty, Staff and Student Publications. 4457.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4457