Perfusion-Weighted Imaging With Dynamic Contrast Enhancement (PWI/DCE) Morphologic, Qualitative, Semiquantitative, and Radiomics Features Predicting Undifferentiated Pleomorphic Sarcoma (UPS) Treatment Response

Authors

R F Valenzuela
E Duran-Sierra
M Canjirathinkal
B Amini
K E Torres
R S Benjamin
J Ma
W L Wang
K P Hwang
R J Stafford
C Wu
A M Zarzour
A J Bishop
S Lo
J E Madewell
R Kumar
W A Murphy
C M Costelloe

Publication Date

9-17-2024

Journal

Scientific Reports

DOI

10.1038/s41598-024-72780-7

PMID

39289469

PMCID

PMC11408515

PubMedCentral® Posted Date

9-17-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Undifferentiated pleomorphic sarcoma (UPS) is the largest subgroup of soft tissue sarcomas. This study determined the value of perfusion-weighted imaging with dynamic-contrast-enhancement (PWI/DCE) morphologic, qualitative, and semiquantitative features for predicting UPS pathology-assessed treatment effect (PATE). This retrospective study included 33 surgically excised extremity UPS patients with pre-surgical MRI. Volumetric tumor segmentation from PWI/DCE was obtained at Baseline (BL), Post-Chemotherapy (PC), and Post-Radiation Therapy (PRT). The surgical specimens' PATE separated cases into Responders (R) (≥ 90%, 16 patients), Partial-Responders (PR) (89 - 31%, 10 patients), and Non-Responders (NR) (≤ 30%, seven patients). Seven semiquantitative kinetic parameters and maps were extracted from time-intensity curves (TICs), and 107 radiomic features were derived. Statistical analyses compared R vs. PR/NR. At PRT, 79% of R displayed a "Capsular" morphology (P = 1.49 × 10-7), and 100% demonstrated a TIC-type II (P = 8.32 × 10-7). 80% of PR showed "Unipolar" morphology (P = 1.03 × 10-5), and 60% expressed a TIC-type V (P = 0.06). Semiquantitative wash-in rate (WiR) was able to separate R vs. PR/NR (P = 0.0078). The WiR radiomics displayed significant differences in the first_order_10 percentile (P = 0.0178) comparing R vs. PR/NR at PRT. The PWI/DCE TIC-type II curve, low WiR, and "Capsular" enhancement represent PRT patterns typically observed in successfully treated UPS and demonstrate potential for UPS treatment response assessment.

Keywords

Humans, Female, Male, Middle Aged, Aged, Adult, Retrospective Studies, Sarcoma, Contrast Media, Treatment Outcome, Magnetic Resonance Imaging, Aged, 80 and over, Radiomics, Dynamic contrast enhancement (DCE), Multiparametric MRI, Pathology-assessed treatment effect (PATE), Perfusion-weighted imaging (PWI), Soft tissue sarcoma (STS), Undifferentiated pleomorphic sarcoma (UPS)

Published Open-Access

yes

Recommended Citation

Valenzuela, R F; Duran-Sierra, E; Canjirathinkal, M; et al., "Perfusion-Weighted Imaging With Dynamic Contrast Enhancement (PWI/DCE) Morphologic, Qualitative, Semiquantitative, and Radiomics Features Predicting Undifferentiated Pleomorphic Sarcoma (UPS) Treatment Response" (2024). Faculty, Staff and Student Publications. 4526.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4526