Faculty, Staff and Student Publications

Publication Date

8-1-2024

Journal

International Journal of Hematology

DOI

10.1007/s12185-024-03787-z

PMID

38748089

PMCID

PMC11809101

PubMedCentral® Posted Date

8-1-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Study aims: To evaluate the outcomes of patients with 3q26.2/MECOM-rearranged chronic myeloid leukemia (CML).

Methods: We reviewed consecutive adult patients with 3q26.2/MECOM-rearranged CML between January 1, 1998 and February 16, 2023. Rearrangements of 3q26.2/MECOM were confirmed by conventional cytogenetics, and fluorescence in situ hybridization starting in 2015.

Results: We identified 55 patients with MECOM-rearranged CML, including 23 in chronic phase (CP) or accelerated phase (AP) and 32 in blast phase (BP). Nine patients (16%) achieved a major cytogenetic response (MCyR) or deeper. At a median follow-up of 89 months, median survival was 14 months. The 5-year survival rate was 19% overall, 23% in CML-CP/AP, and 15% in CML-BP. In the 6-month landmark analysis, the 5-year survival rate was 41% for allogeneic stem cell transplantation (allo-SCT) recipients versus 17% for non-recipients (P = 0.050). Multivariate analysis showed that the percentage of marrow blasts and achievement of MCyR or deeper could predict survival.

Conclusion: Outcomes of 3q26.2/MECOM-rearranged CML are poor despite the availability of multiple BCR::ABL1 tyrosine kinase inhibitors (TKIs). Third-generation TKIs in combination with novel agents and possible allo-SCT could be considered given the poor outcomes and resistance to second-generation TKIs.

Keywords

Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Young Adult, Chromosomes, Human, Pair 3, Follow-Up Studies, Gene Rearrangement, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Retrospective Studies, Survival Rate, Treatment Outcome, Chronic myeloid leukemia, MECOM, tyrosine kinase inhibitors, stem cell transplant

Published Open-Access

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