Faculty, Staff and Student Publications

Raghu Kalluri

Publication Date

8-13-2024

Journal

Immunity

DOI

10.1016/j.immuni.2024.07.009

PMID

39142276

PMCID

PMC11401063

PubMedCentral® Posted Date

8-13-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Extracellular vesicles (EVs), such as ectosomes and exosomes, contain DNA, RNA, proteins and are encased in a phospholipid bilayer. EVs provide intralumenal cargo for delivery into the cytoplasm of recipient cells with an impact on the function of immune cells, in part because their biogenesis can also intersect with antigen processing and presentation. Motile EVs from activated immune cells may increase the frequency of immune synapses on recipient cells in a proximity-independent manner for local and long-distance modulation of systemic immunity in inflammation, autoimmunity, organ fibrosis, cancer, and infections. Natural and engineered EVs exhibit the ability to impact innate and adaptive immunity and are entering clinical trials. EVs are likely a component of an optimally functioning immune system, with the potential to serve as immunotherapeutics. Considering the evolving evidence, it is possible that EVs could be the original primordial organic units that preceded the creation of the first cell.

Keywords

Humans, Extracellular Vesicles, Animals, Immunity, Innate, Adaptive Immunity, Antigen Presentation, Immunity

Published Open-Access

yes

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