Fibroblast Dynamics During Mammary Oncogenesis: Senescence, Wnt9a and Beyond

Authors

Viktoria Boeker
Raghu Kalluri

Publication Date

6-1-2025

Journal

The EMBO Journal

DOI

10.1038/s44318-025-00446-9

PMID

40312497

PMCID

PMC12130480

PubMedCentral® Posted Date

5-1-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Mammary gland fibroblasts are highly plastic and transition through distinct states during development and disease. A new study by Pascual et al (2025) provides a comprehensive single-cell atlas of murine mammary stromal cell hierarchies, revealing dysregulation of progenitor-driven fibroblast lineages in breast cancer and a senescence role of Wnt9a in cancer-associated myofibroblasts.

Keywords

Cancer, Cell Adhesion, Polarity & Cytoskeleton; Development

Published Open-Access

yes

Recommended Citation

Viktoria Boeker and Raghu Kalluri, "Fibroblast Dynamics During Mammary Oncogenesis: Senescence, Wnt9a and Beyond" (2025). Faculty, Staff and Student Publications. 4557.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4557