Faculty, Staff and Student Publications
Islet Single-Cell Transcriptomic Profiling During Obesity-Induced Beta Cell Expansion in Female Mice
Publication Date
3-21-2025
Journal
iScience
DOI
10.1016/j.isci.2025.112031
PMID
40104055
PMCID
PMC11914824
PubMedCentral® Posted Date
2-15-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Targeting beta cell proliferation is an appealing approach to restore glucose control in type 1 diabetes. However, the underlying mechanisms of beta cell proliferation remain incompletely understood, limiting identification of new therapeutic targets. Obesity is a naturally occurring process that potently induces human and rodent beta cell replication, representing an ideal model to study mechanisms of beta cell proliferation. We showed previously acute whole-body
Published Open-Access
yes
Recommended Citation
Masschelin, Peter M; Ochsner, Scott A; Hartig, Sean M; et al., "Islet Single-Cell Transcriptomic Profiling During Obesity-Induced Beta Cell Expansion in Female Mice" (2025). Faculty, Staff and Student Publications. 4567.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4567
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