Faculty, Staff and Student Publications

Publication Date

10-26-2024

Journal

The Journal for ImmunoTherapy of Cancer

DOI

10.1136/jitc-2024-009721

PMID

39461879

PMCID

PMC11529678

PubMedCentral® Posted Date

10-26-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Immuno-oncology has transformed the treatment of cancer, with several immunotherapies becoming the standard treatment across histologies. Despite these advancements, the majority of patients do not experience durable clinical benefits, highlighting the imperative for ongoing advancement in immuno-oncology. Computational immuno-oncology emerges as a forefront discipline that draws on biomedical data science and intersects with oncology, immunology, and clinical research, with the overarching goal to accelerate the development of effective and safe immuno-oncology treatments from the laboratory to the clinic. In this review, we outline 10 critical challenges and opportunities in computational immuno-oncology, emphasizing the importance of robust computational strategies and interdisciplinary collaborations amid the constantly evolving interplay between clinical needs and technological innovation.

Keywords

Humans, Immunotherapy, Medical Oncology, Neoplasms, Computational Biology, Immunotherapy, Biomarker, Education, Immune related adverse event - irAE, Statistics

Published Open-Access

yes

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