Faculty, Staff and Student Publications

Publication Date

2-3-2023

Journal

Science Advances

Abstract

One of the major obstacles to treating pancreatic ductal adenocarcinoma (PDAC) is its immunoresistant microenvironment. The functional importance and molecular mechanisms of Schwann cells in PDAC remains largely elusive. We characterized the gene signature of tumor-associated nonmyelinating Schwann cells (TASc) in PDAC and indicated that the abundance of TASc was correlated with immune suppressive tumor microenvironment and the unfavorable outcome of patients with PDAC. Depletion of pancreatic-specific TASc promoted the tumorigenesis of PDAC tumors. TASc-expressed long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (

Keywords

Humans, Carcinoma, Pancreatic Ductal, Cell Line, Tumor, Cell Proliferation, Gene Expression Regulation, Neoplastic, Kynurenine, Pancreatic Neoplasms, RNA, Long Noncoding, Tumor Microenvironment

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