Faculty, Staff and Student Publications
Publication Date
11-12-2022
Journal
BMC Medical Education
DOI
10.1186/s12909-022-03847-0
PMID
36371179
PMCID
PMC9652913
PubMedCentral® Posted Date
11-12-2022
PubMedCentral® Full Text Version
Post-print
Abstract
Background: The availability of new immuno-oncology therapeutics markedly impacts oncology clinicians' treatment decision-making. To effectively support healthcare professionals (HCPs) in their practice, it is important to better understand the challenges and barriers that can accompany the introduction of these agents. This study aimed to establish the types and causes of clinical challenges posed by the introduction of new immuno-oncology agents.
Methods: The mixed-methods design included qualitative in-depth interviews and group discussions with HCPs, in which participants discussed clinical challenges and potential underlying reasons for these challenges. Qualitative findings informed a quantitative survey. This survey investigated the extent and distribution of challenges using HCPs' self-rating of knowledge, skill, confidence, and exposure to system-level effects. These two phases were conducted sequentially with distinctly stratified samples of oncologists, nurse practitioners (NPs), physician assistants (PAs), pathologists, clinical pharmacists, interventional radiologists, rheumatologists, pulmonologists, and emergency department physicians. Participants were from the United States and had various levels of clinical experience and represented both academic and community-based settings.
Results: The final sample included 107 HCPs in the qualitative phase and 554 in the quantitative phase. Analyses revealed clinical challenges related to the use of pharmacodiagnostics. For example, 47% of pathologists and 42% of oncologists reported skill gaps in identifying the appropriate marker and 46% of oncologists, 61% of PAs, 66% of NPs, 74% of pulmonologists and 81% of clinical pharmacists reported skill gaps in selecting treatment based on test results. Challenges also emerged regarding the integration of immuno-oncology agents, as oncologists, rheumatologists, pulmonologists, clinical pharmacists, PAs, and NPs reported knowledge gaps (74-81%) of the safety profiles of recently approved agents. In addition, 90% of clinical pharmacists reported skill gaps weighing the risks and benefits of treating patients with immuno-oncology agents while affected by lupus. Finally, patient communication challenges were identified: HCPs reported difficulties discussing essential aspects of immunotherapy to patients as well as how they might compare to other types of therapies.
Conclusion: The challenges highlighted in this study reveal substantial educational gaps related to the integration of immuno-oncology agents into practice for various groups of HCPs. These findings provide a strong base of evidence for future educational initiatives.
Keywords
Humans, Medical Oncology, Neoplasms, Health Personnel, Communication, Nurse Practitioners, Challenges and barriers, Continuing medical education, Immuno-oncology, Needs assessment, Patient-provider communication, Pharmacodiagnostics, Challenges and barriers, Continuing medical education, Immuno-oncology, Needs assessment, Patient-provider communication, Pharmacodiagnostics
Published Open-Access
yes
Recommended Citation
Lazure, Patrice; Parikh, Aparna R; Ready, Neal E; et al., "Challenges Associated With the Integration of Immuno-Oncology Agents in Clinical Practice" (2022). Faculty, Staff and Student Publications. 4678.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4678
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Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons