Faculty, Staff and Student Publications

Publication Date

9-1-2024

Journal

NAR Cancer

DOI

10.1093/narcan/zcae037

PMID

39329012

PMCID

PMC11426327

PubMedCentral® Posted Date

9-26-2024

PubMedCentral® Full Text Version

Post-print

Abstract

The p53 tumor suppressor gene governs a multitude of complex cellular processes that are essential for anti-cancer function and whose dysregulation leads to aberrant gene transcription, activation of oncogenic signaling and cancer development. Although mutations can occur at any point in the genetic sequence, missense mutations comprise the majority of observed p53 mutations in cancers regardless of whether the mutation is germline or somatic. One biological process involved in both mutant and wild-type p53 signaling is the

Published Open-Access

yes

zcae037figgra1.jpg (96 kB)
Graphical Abstract

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.