Faculty, Staff and Student Publications

Publication Date

7-25-2025

Journal

Science Advances

DOI

10.1126/sciadv.adi2370

PMID

40712032

PMCID

PMC12292934

PubMedCentral® Posted Date

7-25-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Breast cancer is the most common malignancy in females and remains the leading cause of cancer-related deaths for women worldwide. The cellular and molecular basis of breast tumorigenesis is not completely understood partly due to the lack of human research models which simulate the development of breast cancer. Here, we developed a method for generating functional mammary-like cells (MCs) from human-induced pluripotent stem cells (iPSCs). The iPSC-MCs closely resemble human primary MCs at cellular, transcriptional, and functional levels. Using this method, a breast cancer model was generated using patient-derived iPSCs harboring germline

Keywords

Humans, Breast Neoplasms, BRCA1 Protein, Female, Induced Pluripotent Stem Cells, Mutation, Neoplastic Stem Cells, Gene Expression Regulation, Neoplastic, Animals, Cell Line, Tumor, Mice, Neoplasm Proteins

Published Open-Access

yes

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.