Partial Cystectomy for Muscle-Invasive Bladder Cancer

Authors

Peter S Palencia
Nethusan Sivanesan
Syed Rahman
Fady Ghali
David Hesse
John Colberg
Ashwin Sridhar
John D Kelly
Byron H Lee
Ashish M Kamat
Wei-Shen Tan

Publication Date

8-3-2025

Journal

Cancers

DOI

10.3390/cancers17152562

PMID

40805257

PMCID

PMC12346575

PubMedCentral® Posted Date

8-3-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Partial cystectomy is a surgical bladder-sparing option for selected patients with muscle-invasive bladder cancer (MIBC), urachal adenocarcinoma and diverticular bladder tumors. Partial cystectomy hold several advantages. It allows for definite pathology and accurate staging while avoiding side effects from radiation therapy and preserves the option for salvage radical therapy (radical cystectomy or radical radiotherapy). Patients should have a CT urogram, prostatic urethral biopsy and mapping biopsies or blue light cystoscopy to rule out multifocal disease or CIS. Small solitary MIBC patients without carcinoma in situ in an area of the bladder where resection can be performed with negative margin would be the ideal candidates for partial cystectomy. Neoadjuvant systemic therapy is recommended for patients undergoing partial cystectomy. Partial cystectomy can be performed either by open or robotic approaches. When compared to radical cystectomy, partial cystectomy affords a lower complication rate and length of stay and better quality of life. Recurrence-free survival, cancer-specific survival and overall survival at 5 years is 39-67%, 62-84% and 45-70%, respectively. Following partial cystectomy, patients should have three monthly cystoscopy and urinary cytology for the first 24 months followed by 6-monthly cystoscopy for year 3 and 4 and then yearly for life. Cross-sectional imaging should be performed every 3-6 months for the first 2-3 years and then annually for 5 years.

Keywords

muscle-invasive bladder cancer (MIBC), urachal adenocarcinoma, diverticular bladder tumors, Partial cystectomy

Published Open-Access

yes

Recommended Citation

Palencia, Peter S; Sivanesan, Nethusan; Rahman, Syed; et al., "Partial Cystectomy for Muscle-Invasive Bladder Cancer" (2025). Faculty, Staff and Student Publications. 4698.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4698