Faculty, Staff and Student Publications
Publication Date
1-1-2022
Journal
Oncoimmunology
DOI
10.1080/2162402X.2022.2124678
PMID
36185804
PMCID
PMC9519023
PubMedCentral® Posted Date
9-22-2022
PubMedCentral® Full Text Version
Post-print
Abstract
Acute kidney injury (AKI) occurs in ~20% of patients receiving immune checkpoint inhibitor (ICI) therapy; however, only 2-5% will develop ICI-mediated immune nephritis. Conventional tests are nonspecific in diagnosing disease pathology and invasive procedures (i.e. kidney biopsy) may not be feasible. In other autoimmune renal diseases, urinary immune cells correlated with the pathology or were predictive of disease activity. Corresponding evidence and analysis are absent for ICI-mediated immune nephritis. We report the first investigation analyzing immune cell profiles of matched kidney biopsies and urine of patients with ICI-AKI. We demonstrated the presence of urinary T cells in patients with immune nephritis by flow cytometry analysis. Clonotype analysis of T cell receptor (TCR) sequences confirmed enrichment of kidney TCRs in urine. As ICI therapies become standard of care for more cancers, noninvasively assessing urinary immune cells of ICI therapy recipients can facilitate clinical management and an opportunity to tailor ICI-nephritis treatment.
Keywords
Acute Kidney Injury, Humans, Immune Checkpoint Inhibitors, Kidney, Nephritis, T-Lymphocytes
Published Open-Access
yes
Recommended Citation
Singh, Shailbala; Clemente, Leticia C; Parra, Edwin R; et al., "Urinary T Cells Are Detected in Patients With Immune Checkpoint Inhibitor-Associated Immune Nephritis That Are Clonotypically Identical to Kidney T Cell Infiltrates" (2022). Faculty, Staff and Student Publications. 4773.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4773
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