Omics Analyses of a Somatic Trp53R245W/+ Breast Cancer Model Identify Cooperating Driver Events Activating PI3K/AKT/mTOR Signaling

Authors

Xiaojie Yu
Yun Zhang
Shunbin Xiong
Joy M McDaniel
Chang Sun
Gilda P Chau
Jovanka Gencel-Augusto
Dhruv Chachad
Rhiannon L Morrissey
Xiayu Rao
Jing Wang
Guillermina Lozano

Publication Date

11-8-2022

Journal

Proceedings of the National Academy of Sciences of the United States of America

DOI

10.1073/pnas.2210618119

PMID

36322759

PMCID

PMC9659373

PubMedCentral® Posted Date

11-2-2022

PubMedCentral® Full Text Version

Post-print

Abstract

Alterations of the tumor suppressor

Keywords

Animals, Female, Humans, Mice, Breast Neoplasms, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Signal Transduction, TOR Serine-Threonine Kinases, Tumor Suppressor Protein p53

Published Open-Access

yes

Recommended Citation

Yu, Xiaojie; Zhang, Yun; Xiong, Shunbin; et al., "Omics Analyses of a Somatic Trp53R245W/+ Breast Cancer Model Identify Cooperating Driver Events Activating PI3K/AKT/mTOR Signaling" (2022). Faculty, Staff and Student Publications. 4787.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4787