Faculty, Staff and Student Publications

Publication Date

2-1-2024

Journal

Journal of Vascular and Interventional Radiology

DOI

10.1016/j.jvir.2023.09.035

PMID

38272640

PMCID

PMC12302019

PubMedCentral® Posted Date

7-28-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Immunotherapy has revolutionized cancer management, but many tumors, particularly immunologically "cold" tumors, remain resistant to the therapy. The combination of conventional systemic immunotherapies and locoregional interventional radiology approaches is being explored to transform these cold tumors into immunologically active "hot" ones. The present article uses the example of chromophobe renal cell carcinoma (ChRCC), a renal cell carcinoma subtype resistant to current systemic immunotherapies, to address practical and conceptual challenges that have prevented the activation of clinical trials specifically designed for this malignancy to date. The practical framework discussed herein can help overcome logistic and funding limitations and facilitate the development of biology-informed clinical trials tailored to specific rare diseases such as ChRCC.

Keywords

Humans, Clinical Trials as Topic, Carcinoma, Renal Cell, Immunotherapy, Kidney Neoplasms

Published Open-Access

yes

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