Faculty, Staff and Student Publications
Publication Date
6-1-2024
Journal
Expert Review of Anticancer Therapy
DOI
10.1080/14737140.2024.2343801
PMID
38646700
Abstract
Introduction: Studies have compared chimeric antigen receptor (CAR) T-cell therapies and salvage chemotherapy in relapsed/refractory large B-cell lymphoma (LBCL) patients, but further evidence of their relative effectiveness is warranted.
Methods: Our systematic review identified studies comparing efficacy and safety outcomes of axicabtagene ciloleucel (axi-cel), lisocabtagene maraleucel (liso-cel) and tisagenlecleucel (tisa-cel) trials to salvage chemotherapy cohorts in LBCL patients with ≥2 prior lines of treatment; and an extended evidence network included indirect comparisons comparing CAR T-cell therapies. We conducted network meta-analyzes using Bayesian hierarchical modeling.
Results: Three studies comparing ZUMA-1 (axi-cel), TRANSCEND (liso-cel) and JULIET (tisa-cel) trials to salvage chemotherapy within the SCHOLAR-1 cohort were identified. Axi-cel (odds ratio [OR]:5.63; 95% credible interval [CrI]:2.66-12.42) and liso-cel (OR:4.26; 95%CrI:2.33-7.93) showed a significant increased overall response rate compared to tisa-cel, but not to one-another. Axi-cel demonstrated significant improvements in overall survival relative to liso-cel (hazard ratio [HR]:0.54; 95%CrI:0.37-0.79) and tisa-cel (HR:0.47; 95%CrI:0.26-0.88). Higher rates of grade ≥3 neurological events were observed with axi-cel than with tisa-cel and liso-cel.
Conclusions: We highlight important differences in clinical outcomes between CAR T-cell therapies. Axi-cel demonstrated improved overall survival compared to tisa-cel and liso-cel, and both axi-cel and liso-cel showed higher response rates compared to tisa-cel.
Keywords
Humans, Bayes Theorem, Biological Products, Immunotherapy, Adoptive, Lymphoma, Large B-Cell, Diffuse, Receptors, Antigen, T-Cell, Receptors, Chimeric Antigen, Salvage Therapy, CAR T-cells, Indirect treatment comparisons, axi-cel, large B-cell lymphoma, liso-cel
Published Open-Access
yes
Recommended Citation
Oluwole, Olalekan O; Neelapu, Sattva S; Ray, Markqayne D; et al., "Network Meta-Analysis of CAR T-Cell Therapy for the Treatment of 3L+ R/R LBCL After Using Published Comparative Studies" (2024). Faculty, Staff and Student Publications. 4900.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4900
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons