Lacrimal Gland Adenocarcinoma Clinicopathologic Features and Outcomes Compared With Those of Lacrimal Gland Adenoid Cystic Carcinoma

Authors

Hila Goldberg
Xinyang Jiang
Janet Fan
Jiawei Zhao
Jing Ning
Michelle Williams
Steven Frank
Amy Moreno
Brandon Gunn
Renata Ferrarotto
Bita Esmaeli

Publication Date

7-1-2024

Journal

Ophthalmic Plastic & Reconstructive Surgery

DOI

10.1097/IOP.0000000000002606

PMID

38319188

PMCID

PMC11226383

PubMedCentral® Posted Date

7-3-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Purpose: Lacrimal gland (LG) adenocarcinomas (ACs) are rare, with limited data. We compared clinicopathologic features and local recurrence, distant metastasis, and survival rates between LG AC and LG adenoid cystic carcinoma (ACC).

Methods: The records of LG AC patients treated from 2008 to 2022 and LG ACC patients treated from 1998 to 2022 at the same center were retrospectively reviewed.

Results: The study included 20 patients with AC; 10 de-novo AC, 10 ex-pleomorphic AC; and 51 ACC patients. The median age at diagnosis was 61 years for de-novo AC, 54 years for ex-pleomorphic AC, and 45 years for ACC. All groups had male predominance. The initial T category was T2 in 50% (5/10) of de-novo ACs; 60% (6/10) of ex-pleomorphic ACs; and 59% (30/51) of ACCs. Perineural invasion was present in 33% (5/15) of ACs and 90% (45/50) of ACCs ( p < 0.001). Of the 20 AC patients, 14 had eye-sparing surgery; 4 had orbital exenteration; and 2 had unresectable disease. All AC patients received postoperative radiotherapy and 15 (75%) received concurrent chemotherapy. Fourteen AC patients were tested for human growth factor receptor 2 expression, and 10 (71%) were human growth factor receptor 2 positive; 5 received human growth factor receptor 2-targeted therapy. AC and ACC had similar 5-year recurrence rates (20% and 33%, respectively, p = 0.31) and metastasis rates (20% and 34%, respectively, p = 0.30). de-novo AC, ex-pleomorphic AC, and ACC had similar 5-year disease-specific survival rates (80%, 79%, and 81%, respectively, p > 0.99).

Conclusions: LG AC and ACC have similar baseline clinicopathologic features, except that perineural invasion is more common in ACC, and similar recurrence, metastasis, and survival rates. Human growth factor receptor 2-targeted therapy may be appropriate in some patients with LG AC.

Keywords

Humans, Male, Carcinoma, Adenoid Cystic, Middle Aged, Female, Retrospective Studies, Lacrimal Apparatus Diseases, Eye Neoplasms, Aged, Adult, Adenocarcinoma, Neoplasm Recurrence, Local, Survival Rate, Aged, 80 and over, Lacrimal Apparatus

Published Open-Access

yes

Recommended Citation

Goldberg, Hila; Jiang, Xinyang; Fan, Janet; et al., "Lacrimal Gland Adenocarcinoma Clinicopathologic Features and Outcomes Compared With Those of Lacrimal Gland Adenoid Cystic Carcinoma" (2024). Faculty, Staff and Student Publications. 4911.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4911