Faculty, Staff and Student Publications
Publication Date
6-1-2025
Journal
Journal of Applied Clinical Medical Physics
DOI
10.1002/acm2.70023
PMID
40048322
PMCID
PMC12148799
PubMedCentral® Posted Date
3-6-2025
PubMedCentral® Full Text Version
Post-print
Abstract
INTRODUCTION: This work presents a multi-institutional study on image quality provided by a novel cone beam computed tomography (CBCT). The main goal is to investigate the consistency of imaging performance across multiple institutions.
METHODS: Phantoms for measuring relative electron density (RED) and image quality were sent to six institutions for imaging on Ethos and Halcyon units equipped with HyperSight CBCT. The imaging protocols included tube potential from 100 to 140 kVp and exposure from 80 to 800 mAs. Imaging performance was evaluated with regard to RED versus Hounsfield units (HU), uniformity, contrast-to-noise ratio (CNR), slice thickness, circular symmetry, modulation transfer function (MTF), and spatial resolution.
RESULTS: Among all institutions, some variability was observed among institutions in the RED-to-HU relationship, especially for RED values greater than 1, although no outliers were found (|z-score| < 2 in all cases). In this range, RED/HU slopes were 475 ± 25 10
CONCLUSIONS: This multi-institutional analysis of CBCT imaging performance showed consistency in radial uniformity, circular symmetry, integral nonuniformity, contrast, and spatial resolution. Some variability was seen in the RED-to-HU relationship for RED > 1 depending on exposure. More data from different institutions would be necessary to establish more robust statistical metrics, which ensure quality parameters.
Keywords
Cone-Beam Computed Tomography, Particle Accelerators, Humans, Phantoms, Imaging, Image Processing, Computer-Assisted, Radiotherapy Planning, Computer-Assisted, Radiotherapy Dosage, Radiotherapy, Intensity-Modulated, Signal-To-Noise Ratio
Published Open-Access
yes
Recommended Citation
Agulles-Pedrós, Luis; MacDonald, R Lee; Cherpak, Amanda Jean; et al., "Multi-Institutional Study on Image Quality for a Novel CBCT Solution on O-Ring Linac" (2025). Faculty, Staff and Student Publications. 5031.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5031
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons