The Lure of Cardiac Metabolism in the Diagnosis, Prevention, and Treatment of Heart Failure

Authors

Daniele Rodolico
Gabriele G Schiattarella
Heinrich Taegtmeyer

Publication Date

6-1-2023

Journal

JACC: Heart Failure

DOI

10.1016/j.jchf.2023.02.007

PMID

10.1016/j.jchf.2023.02.007

PubMedCentral® Posted Date

6-1-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Energy substrate metabolism and contractile function are tightly coupled in the heart. Within this framework, heart failure may be viewed as a state of impaired energy transfer. The metabolic changes in the failing heart are linked to functional and structural changes. A worthwhile goal is to measure metabolic flux and its regulation quantitatively, and to do this in a manner that leads to targeted interventions. For several good reasons, this goal has been elusive until now. The development of new analytical and imaging techniques offers the potential of exploring the landscape of metabolic changes across the different stages of heart failure. In this Review Topic of the Month, the authors focus on concepts and brevity to provide a strategic overview of cardiac metabolism in the diagnosis, prevention, and treatment of nonischemic heart failure.

Keywords

Humans, Heart Failure, Myocardium, Heart, Energy Metabolism

Published Open-Access

yes

Recommended Citation

Daniele Rodolico, Gabriele G Schiattarella, and Heinrich Taegtmeyer, "The Lure of Cardiac Metabolism in the Diagnosis, Prevention, and Treatment of Heart Failure" (2023). Faculty, Staff and Student Publications. 5034.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5034