Faculty, Staff and Student Publications
Publication Date
6-1-2024
Journal
American Society of Clinical Oncology Educational Book
DOI
10.1200/EDBK_433576
PMID
38913968
Abstract
Germline pathogenic variants (PVs) in the BRCA1 and BRCA2 genes confer elevated risks of breast, ovarian, and other cancers. Lynch syndrome (LS) is associated with increased risks of multiple cancer types including colorectal and uterine cancers. Current cancer risk mitigation strategies have focused on pharmacologic risk reduction, enhanced surveillance, and preventive surgeries. While these approaches can be effective, they stand to be improved on because of either limited efficacy or undesirable impact on quality of life. The current review summarizes ongoing investigational efforts in cancer risk prevention strategies for patients with germline PVs in BRCA1, BRCA2, or LS-associated genes. These efforts span radiation, surgery, and pharmacology including vaccine strategies. Understanding the molecular events involved in the premalignant to malignant transformation in high-risk individuals may ultimately contribute significantly to novel prevention strategies.
Keywords
Humans, Colorectal Neoplasms, Hereditary Nonpolyposis, BRCA1 Protein, BRCA2 Protein, Genetic Predisposition to Disease, Female, Neoplastic Syndromes, Hereditary, Germ-Line Mutation
Published Open-Access
yes
Recommended Citation
Bowen, Charles M; Demarest, Kaitlin; Vilar, Eduardo; et al., "Novel Cancer Prevention Strategies in Individuals With Hereditary Cancer Syndromes: Focus on BRCA1, BRCA2, and Lynch Syndrome" (2024). Faculty, Staff and Student Publications. 5074.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5074
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons