Immunoprevention Strategies for Colorectal Cancer in Lynch Syndrome Carriers

Authors

Charles M Bowen
Krishna M Sinha
Eduardo Vilar

Publication Date

9-1-2024

Journal

Cancer Journal

DOI

10.1097/PPO.0000000000000738

PMID

39312455

PMCID

PMC11424018

PubMedCentral® Posted Date

1-1-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

The immune revolution that swept the field of oncology in the mid-2010s with the advent of checkpoint inhibitors has led to a paradigm shift in approaches toward adapting new cancer prevention modalities. Cancer vaccines have emerged from this era with astounding potential as a durable intervention to prevent cancers especially for patients with hereditary susceptibilities such as Lynch syndrome carriers. This review covers new insights in the immunoprevention landscape for patients living with Lynch syndrome including highlights ranging from clinical trials exploring the use of chemoprevention agents to boost immune cellularity to investigative studies using novel vaccine approaches to induce long-term antitumor immunity.

Keywords

Humans, Colorectal Neoplasms, Hereditary Nonpolyposis, Cancer Vaccines, Immunotherapy, Immune Checkpoint Inhibitors, Chemoprevention, Colorectal Neoplasms

Published Open-Access

yes

Recommended Citation

Charles M Bowen, Krishna M Sinha, and Eduardo Vilar, "Immunoprevention Strategies for Colorectal Cancer in Lynch Syndrome Carriers" (2024). Faculty, Staff and Student Publications. 5075.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5075