Electronic Patient-Reported Outcome-Based Symptom Management Versus Usual Care After Lung Cancer Surgery: Long-Term Results of a Multicenter, Randomized, Controlled Trial

Authors

Wei Dai
Yaqin Wang
Jia Liao
Xing Wei
Zhen Dai
Wei Xu
Yangjun Liu
Xin Shelley Wang
Cecilia Pompili
Hongfan Yu
Yang Pu
Yuqian Zhao
Bangrong Cao
Qifeng Wang
Wenhong Feng
Yuanqiang Zhang
Fang Liu
Yuanle Deng
Jin Zhou
Juan Li
Shaohua Xie
Run Xiang
Xiang Wang
Bo Tian
Xiaozun Yang
Bin Hu
Xiaoqin Liu
Tianpeng Xie
Xiaojun Yang
Xiang Zhuang
Guibin Qiao
Qiang Li
Qiuling Shi

Publication Date

6-20-2024

Journal

Journal of Clinical Oncology

DOI

10.1200/JCO.23.01854

PMID

38574304

PMCID

PMC11191061

PubMedCentral® Posted Date

4-4-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.We previously reported superior symptom control of electronic patient-reported outcome (ePRO)-based symptom management after lung cancer surgery for up to 1 month postdischarge. Here, we present the long-term results (1-12 months) of this multicenter, randomized trial, where patients were assigned 1:1 to receive postoperative ePRO-based symptom management or usual care daily postsurgery, twice weekly postdischarge until 1 month, and at 3, 6, 9, and 12 months postdischarge. Long-term patient-reported outcomes were assessed with MD Anderson Symptom Inventory-Lung Cancer module. Per-protocol analyses were performed with 55 patients in the ePRO group and 57 in the usual care group. At 12 months postdischarge, the ePRO group reported significantly fewer symptom threshold events (any of the five target symptom scored ≥4; median [IQR], 0 [0-0] v 0 [0-1]; P = .040) than the usual care group. From 1 to 12 months postdischarge, the ePRO group consistently reported significantly lower composite scores for physical interference (estimate, -0.86 [95% CI, -1.32 to -0.39]) and affective interference (estimate, -0.70 [95% CI, -1.14 to -0.26]). Early intensive ePRO-based symptom management after lung cancer surgery reduced symptom burden and improved functional status for up to 1 year postdischarge, supporting its integration into standard care.

Keywords

Humans, Patient Reported Outcome Measures, Lung Neoplasms, Female, Male, Aged, Middle Aged, Quality of Life

Published Open-Access

yes

Recommended Citation

Dai, Wei; Wang, Yaqin; Liao, Jia; et al., "Electronic Patient-Reported Outcome-Based Symptom Management Versus Usual Care After Lung Cancer Surgery: Long-Term Results of a Multicenter, Randomized, Controlled Trial" (2024). Faculty, Staff and Student Publications. 5096.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5096