Pathologist-Initiated Reflex Testing for Biomarkers in Non-Small-Cell Lung Cancer: Expert Consensus on the Rationale and Considerations for Implementation

Authors

J R Gosney
L Paz-Ares
P Jänne
K M Kerr
N B Leighl
M D Lozano
U Malapelle
T Mok
B S Sheffield
A Tufman
I I Wistuba
S Peters

Publication Date

8-1-2023

Journal

ESMO Open

DOI

10.1016/j.esmoop.2023.101587

PMID

37356358

PMCID

PMC10485396

PubMedCentral® Posted Date

6-23-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Biomarker tests in lung cancer have been traditionally ordered by the treating oncologist upon confirmation of an appropriate pathological diagnosis. The delay this introduces prolongs yet further what is already a complex, multi-stage, pre-treatment pathway and delays the start of first-line systemic treatment, which is crucially informed by the results of such analysis. Reflex testing, in which the responsibility for testing for an agreed range of biomarkers lies with the pathologist, has been shown to standardise and expedite the process. Twelve experts discussed the rationale and considerations for implementing reflex testing as standard clinical practice.

Keywords

Humans, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Consensus, Pathologists, Biomarkers, Tumor, Reflex, reflex testing, non-small-cell lung cancer, NSCLC, predictive biomarkers, turnaround time, molecular pathology

Published Open-Access

yes

Recommended Citation

Gosney, J R; Paz-Ares, L; Jänne, P; et al., "Pathologist-Initiated Reflex Testing for Biomarkers in Non-Small-Cell Lung Cancer: Expert Consensus on the Rationale and Considerations for Implementation" (2023). Faculty, Staff and Student Publications. 5142.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5142