Faculty, Staff and Student Publications
Publication Date
2-1-2024
Journal
Modern Pathology
DOI
10.1016/j.modpat.2023.100405
PMID
38104893
Abstract
Large or blastoid B-cell neoplasms that are SOX11+ are a diagnostic dilemma and raise a differential diagnosis of cyclin D1-negative blastoid/pleomorphic mantle cell lymphoma (MCL) versus diffuse large B-cell lymphoma (DLBCL) or blastoid high-grade B-cell lymphoma (HGBL) with aberrant SOX11 expression. Here we report a study cohort of 13 SOX11+ large/blastoid B-cell neoplasms. Fluorescence in situ hybridization analysis was negative for CCND1 rearrangement in all 13 cases; 1 of 8 (12.5%) cases tested showed CCND2 rearrangement and 2 (25%) cases had extracopies of CCND2. Gene expression profiling showed that the study group had a gene expression signature similar to cyclin D1+ blastoid/pleomorphic MCL but different from DLBCL. Principal component analysis revealed that the cohort cases overlapped with cyclin D1+ blastoid/pleomorphic MCL but had minimal overlap with DLBCL. All patients in the cohort had clinicopathologic features similar to those reported for patients with cyclin D1+ MCL. We also performed a survey of SOX11 expression in a group of 85 cases of DLBCL and 24 cases of blastoid HGBL. SOX11 expression showed a 100% specificity and positive predictive value for the diagnosis of MCL. Overall, the results support the conclusion that large or blastoid B-cell neoplasms that are positive for SOX11 are best classified as cyclin D1-negative blastoid/pleomorphic MCL, and not as DLBCL or blastoid HGBL. We also conclude that SOX11 is a specific marker for the diagnosis of MCL, including cyclin D1-negative blastoid/pleomorphic MCL cases and should be performed routinely on blastoid/large B-cell neoplasms to help identify potential cases of cyclin D1-negative blastoid/pleomorphic MCL.
Keywords
Adult, Humans, Lymphoma, Mantle-Cell, Cyclin D1, In Situ Hybridization, Fluorescence, Immunohistochemistry, Lymphoma, Large B-Cell, Diffuse, SOXC Transcription Factors, CCND1, CCND2, Cyclin D1-negative mantle cell lymphoma, SOX11, blastoid high-grade B-cell lymphoma, blastoid/pleomorphic, diffuse large B-cell lymphoma
Published Open-Access
yes
Recommended Citation
Li, Shaoying; Tang, Guilin; Jain, Preetesh; et al., "SOX11+ Large B-Cell Neoplasms: Cyclin D1-Negative Blastoid/Pleomorphic Mantle Cell Lymphoma or Large B-Cell Lymphoma?" (2024). Faculty, Staff and Student Publications. 5167.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5167
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons, Pathology Commons