Faculty, Staff and Student Publications

Publication Date

12-1-2024

Journal

Advanced Healthcare Materials

DOI

10.1002/adhm.202402373

PMID

39109957

PMCID

PMC11650432

PubMedCentral® Posted Date

8-7-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Enabling minimally invasive and precise control of liquid release in dental implants is crucial for therapeutic functions such as delivering antibiotics to prevent biofilm formation, infusing stem cells to promote osseointegration, and administering other biomedicines. However, achieving controllable liquid cargo release in dental implants remains challenging due to the lack of wireless and miniaturized fluidic control mechanisms. Here wireless miniature pumps and valves that allow remote activation of liquid cargo delivery in dental implants, actuated and controlled by external magnetic fields (< 65 mT), are reported. A magnet-screw mechanism in a fluidic channel to function as a piston pump, alongside a flexible magnetic valve designed to open and close the fluidic channel, is proposed. The mechanisms are showcased by storing and releasing of liquid up to 52 µL in a dental implant. The liquid cargos are delivered directly to the implant-bone interface, a region traditionally difficult to access. On-demand liquid delivery is further showed by a metal implant inside both dental phantoms and porcine jawbones. The mechanisms are promising for controllable liquid release after implant placement with minimal invasion, paving the way for implantable devices that enable long-term and targeted delivery of therapeutic agents in various bioengineering applications.

Keywords

Dental Implants, Animals, Wireless Technology, Drug Delivery Systems, Swine, Microfluidics, implant, magnetic actuation, pump, targeted drug delivery, valve

Published Open-Access

yes

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