Faculty, Staff and Student Publications
Prefrontal Cortex Astrocytes Modulate Distinct Neuronal Populations To Control Anxiety-Like Behavior
Publication Date
8-21-2025
Journal
Nature Communications
DOI
10.1038/s41467-025-63131-9
PMID
40841557
PMCID
PMC12371101
PubMedCentral® Posted Date
8-21-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Accumulating evidence has supported diverse regulatory functions of astrocytes in different neural circuits as well as various aspects of complex behaviors. However, little is known about how astrocytes regulate different neuronal subpopulations that are linked to specific behavioral aspects within a single brain region. Here, we show that astrocytes in the medial prefrontal cortex (mPFC) encode anxiogenic environmental cues in freely behaving mice. Silencing mPFC astrocyte Ca
Keywords
Animals, Astrocytes, Prefrontal Cortex, Anxiety, Neurons, Mice, Male, Behavior, Animal, Mice, Inbred C57BL, Calcium Signaling, Proteomics
Published Open-Access
yes
Recommended Citation
Kim, Eunyoung; Du, Hairuo; Tan, Yanqi; et al., "Prefrontal Cortex Astrocytes Modulate Distinct Neuronal Populations To Control Anxiety-Like Behavior" (2025). Faculty, Staff and Student Publications. 5182.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5182
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