Faculty, Staff and Student Publications

Publication Date

6-12-2024

Journal

Journal of Clinical Medicine

DOI

10.3390/jcm13123436

PMID

38929965

PMCID

PMC11205088

PubMedCentral® Posted Date

6-12-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Germ cell tumor of the testis (GCT) is a curable cancer even when it is widely metastatic; however, outcomes can differ based on tumor histology. Chemo-resistance in certain phenotypes, such as teratoma and yolk sac tumor, contributes to poor clinical outcomes in some patients with GCT. Despite this resistance to S-YSTemic therapy, many of these tumor subtypes remain amenable to surgical resection and possible cure. In this study, we report on a series of seven patients highlighting two chemo-resistant subtypes of nonseminomatous germ cell tumor (NSGCT), sarcomatoid yolk sac tumor (S-YST), and epithelioid trophoblastic tumor (ETT) for which early resection rather than additional salvage chemotherapy or high-dose intense chemotherapy might provide a superior clinical outcome and enhance cure rate.

Keywords

testicular cancer, sarcomatoid yolk sac tumor, epithelioid trophoblastic tumor, somatic transformation, intratumoral heterogeneity, drug resistance, therapy development

Published Open-Access

yes

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