Reduced Grey Matter Volume in Adolescents With Conduct Disorder: A Region-of-Interest Analysis Using Multivariate Generalized Linear Modeling

Authors

Ru Zhang
R James R Blair
Karina S Blair
Matthew Dobbertin
Jaimie Elowsky
Johannah Bashford-Largo
Ahria J Dominguez
Melissa Hatch
Sahil Bajaj

Publication Date

11-17-2023

Journal

Discover Mental Health

DOI

10.1007/s44192-023-00052-3

PMID

37975932

PMCID

PMC10656392

PubMedCentral® Posted Date

11-17-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Background: Conduct disorder (CD) involves a group of behavioral and emotional problems that usually begins during childhood or adolescence. Structural brain alterations have been observed in CD, including the amygdala, insula, ventrolateral and medial prefrontal cortex, anterior cingulate cortex, and fusiform gyrus. The current study developed a multivariate generalized linear model (GLM) to differentiate adolescents with CD from typically developing (TD) adolescents in terms of grey matter volume (GMV).

Methods: The whole-brain structural MRI data were collected from 96 adolescents with CD (mean age = [Formula: see text] years; mean IQ = [Formula: see text]; 63 males) and 90 TD individuals (mean age = [Formula: see text] years; mean IQ = [Formula: see text]; 59 males) matched on age, IQ, and sex. Region-wise GMV was extracted following whole-brain parcellation into 68 cortical and 14 subcortical regions for each participant. A multivariate GLM was developed to predict the GMV of the pre-hypothesized regions-of-interest (ROIs) based on CD diagnosis, with intracranial volume, age, sex, and IQ serving as the covariate.

Results: A diagnosis of CD was a significant predictor for GMV in the right pars orbitalis, right insula, right superior temporal gyrus, left fusiform gyrus, and left amygdala (F(1, 180) = 5.460-10.317, p < 0.05, partial eta squared = 0.029-0.054). The CD participants had smaller GMV in these regions than the TD participants (MCD-MTD = [- 614.898] mm3-[- 53.461] mm3).

Conclusions: Altered GMV within specific regions may serve as a biomarker for the development of CD in adolescents. Clinical work can potentially target these biomarkers to treat adolescents with CD.

Published Open-Access

yes

Recommended Citation

Zhang, Ru; Blair, R James R; Blair, Karina S; et al., "Reduced Grey Matter Volume in Adolescents With Conduct Disorder: A Region-of-Interest Analysis Using Multivariate Generalized Linear Modeling" (2023). Faculty, Staff and Student Publications. 5211.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5211