Faculty, Staff and Student Publications
Inhibition of the Ufd-1-Npl-4 Complex Triggers an Aberrant Immune Response in Caenorhabditis elegans
Language
English
Publication Date
9-10-2025
Journal
eLife
DOI
10.7554/eLife.94310
PMID
40928215
PMCID
PMC12422736
PubMedCentral® Posted Date
9-10-2025
PubMedCentral® Full Text Version
Post-print
Abstract
The UFD-1 (ubiquitin fusion degradation 1)-NPL-4 (nuclear protein localization homolog 4) heterodimer is involved in extracting ubiquitinated proteins from several plasma membrane locations, including the endoplasmic reticulum. This heterodimer complex helps in the degradation of ubiquitinated proteins via the proteasome with the help of the AAA+ATPase CDC-48. While the ubiquitin-proteasome system is known to have important roles in maintaining innate immune responses, the role of the UFD-1-NPL-4 complex in regulating immunity remains elusive. In this study, we investigate the role of the UFD-1-NPL-4 complex in maintaining
Keywords
Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Pseudomonas aeruginosa, Immunity, Innate
Published Open-Access
yes
Recommended Citation
Rajneesh Rao, Alejandro Aballay, and Jogender Singh, "Inhibition of the Ufd-1-Npl-4 Complex Triggers an Aberrant Immune Response in Caenorhabditis elegans" (2025). Faculty, Staff and Student Publications. 5236.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5236
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